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產品詳情

  • 產品名稱：Moscerdam

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  • 產品廠商：Moscerdam
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簡單介紹：
MoscerdamCertain enzyme assays require additional lysosomal enzymes for their determination. Enzymes not available from other companies, are provided by Moscerdam Substrates as ready-for-use kits (e.g. for Hunter's and Sanfilippo D disease). All substrates are accompanied by detailed laboratory protocols, which are continuously refined through the feedback of customers.Moscerdam
詳情介紹：

Moscerdam

  


Order Code Disease Substrate
INCL
   ????????? 		INCL; CLN1
newly available 		4MU-6-thiopalmitoyl-beta-D-glucoside
    now available from Carbosynth (click INCL)
KRB Krabbe 6HMU-beta-D-galactoside
M2
   ????????? 		MPS II
discontinued
 4MU-alpha-L-iduronide-2-sulphate
   no longer available, click M2 for alternative 
M3A
   ????????? 		MPS III A
newly available  		4MU-alpha-N-sulpho-D-glucosaminide
   now available from Carbosynth (click M3A)
M3C MPS III C 4MU-beta-D-glucosaminide
M3D
   ????????? 		MPS III D 
discontinued 		4MU-alpha-N-acetyl-D-glucosaminide-6-sulphate
       no longer available, click M3D for alternative
M4A
   ????????? 		MPS IV A
discontinued 		4MU-beta-D-galactoside-6-sulphate
       no longer available, click M4A for alternative
NPAB Niemann-Pick A/B 6HMU-phosphorylcholine
ANAGA Schindler 4MU-alpha-N-acetyl-D-galactosaminide


HMU 6-HMU-standard 6-hexadecanoylamino-4-methylumbelliferone


Fluorogenic substrates for the laboratory diagnosis of lysosomal storage diseases

  • Each lot is biochemically tested with fibroblasts from patients, 
    in an academic, lysosomal laboratory
  • Enzymes for "two-step" assays are included
  • Laboratory protocols are continuously upgraded through customer feedback
Moscerdam

History of Moscerdam Substrates

Moscerdam Substrates has been the pioneer for novel substrates for lysosomal enzymes for the last 15 years. During this period all the conventional, cumbersome assays for lysosomal enzymes with radio-labelled substrates have been replaced by robust, fluorogenic assays. The range of substrates was developed in a scientific collaboration between the Institute of Organic Chemistry, Russian Academy of Sciences, Moscow and the Metabolic Unit of the Erasmus MC, Rotterdam, the Netherlands.

Quality Control

Moscerdam substrates are not only of high chemical purity, but more importantly are biochemically pure. Enzyme laboratory practice has shown that chemical purity does not always guarantee optimal performance of enzyme assays. TrACES of impurity (< 1%) can severely jeopardise results. All Moscerdam substrates are tested with fibroblasts from patients with the corresponding lysosomal storage disease. This biochemical testing is the only way to ensure constant high-quality substrates.amc The tests are performed in the Department of Medical Biochemistry, headed by Prof. Hans Aerts at the Academic Medical Centre in Amsterdam in the Netherlands. This department has a long standing experience with lysosomal storage disorders

Special features

Certain enzyme assays require additional lysosomal enzymes for their determination. Enzymes not available from other companies, are provided by Moscerdam Substrates as ready-for-use kits (e.g. for Hunter's and Sanfilippo D disease). All substrates are accompanied by detailed laboratory protocols, which are continuously refined through the feedback of customers.



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